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The “One-Way-Ticket” anthology submission call from Starry Eyed Press, among other requirements, asked for a short story in the science fiction genre that in some way described a one-way journey.
As humanity anticipates the possibility of colonizing the Moon, Mars, or even planets outside our solar system, in at least the last two examples, the people making those trips may well never see the Earth again. Of course, there are all sorts of ways to imagine such a story. Here’s an example of mine: